CBD is metabolized in the liver by Cytochrome P450 (CYP) system and can interfere with metabolism of other medications that use the same system for metabolism, which can result in altered levels especially CYP2C9, CYP2C19, CYP3A4. Known AED medicines are Clobazam, Sodium Valproate, Topiramate. Space CBD 2-4 hours before or after pharmaceutical medication to reduce the likelihood of drug interactions. Consult your prescribing doctor before consuming the cannabis. Blood testing can determine medication levels and enzyme levels in the body. You can repeat this test every 6-8 weeks until a pattern is formed. This test can be a catalyst for medication weaning schedules. Your NHS clinician should be able to help with this. This study provides more in-depth information ; https://realmofcaring.org/wp-content/uploads/2019/10/Interactions-between-cannabidiol-and-commonly-used-antiepileptic-drugs.pdf
Like any medicine, not everyone is suitable for medical cannabis treatment. People with active schizophrenia, for example, may not be suitable as well as some people with heart rhythm problems. Medical cannabis doesn’t mix very well with some other medicines that you might be on. Your doctor will check out whether it is suitable for you before prescribing.
CBD is generally very safe, but can give some people stomach upsets, diarrhoea, dizziness and tiredness. THC has more side effects and these can include dizziness, disorientation, drowsiness and dry mouth, as some examples. However, your doctor will start you on a low dose and increase it gradually so that side effects are minimised. Serious side effects, like a psychotic episode, should be avoided by careful screening of whether you are suitable for treatment in the first place.
You can take more than prescribed, but fortunately no one has died directly from an overdose of cannabis – unlike some medicines like opioids. Overdosing can be unpleasant and can give, for example, palpitations, sweating, dizziness, disorientation and even, in very rare cases, psychotic reactions but these will pass after a few hours. A very large overdose can be serious and If you are concerned, go to A&E and tell them what you have taken.
Some reports have said that THC can damage the developing brain in children and adolescents. There is no evidence of this in the low doses generally used in cannabis medicine. There are some reports of such problems in high THC recreational cannabis users, but those reports are also controversial. In the low THC doses used in medical practice that risk is very small indeed.
No woman should really take any medicine whilst pregnant or breastfeeding. However, occasionally taking some medicine is essential for a medical condition. If your condition necessitates continuing on cannabis (such as epilepsy) then be reassured that there are no definite “syndromes” associated with cannabis. High THC recreational cannabis may cause low birthweight, but the evidence for any other problems in the newborn child is not clear. Avoid if possible.
Properly prescribed medical cannabis treatment by a specialist ensures that you will receive safe products. Prescribed medical cannabis treatment will be EU GMP standard and thus meets high quality standards of consistency. It comes with a certificate of analysis so you can be confident it contains exactly what is required. Your doctor will only prescribe safe products that are suitable for you. Check Lab Analysis under Education in the menu for more information.
This is a carrier oil, which helps to enhance the availability of the cannabis after consumption. MCT oil is arguably the most effective option, however some brands will try other sources, such as olive oil.